An intensive, high-level course on TB diagnostic research methods

Grant support from:

Course Slides

Day 1 (7 July 2014)
Global value chain, pipeline, TPPs, TB diagnostics development

The big picture: global value chain for TB diagnostics - M Pai [Download]
Panel discussion: Scale-up of existing WHO-endorsed tools – country experiences and challenges
Panel discussion: Private sector: how do we scale-up WHO-endorsed tests?
Beyond Xpert: fast-followers and NAAT pipeline - D Boyle [Download]
Panel discussion: Gaps in the pipeline: priority target product profiles
Panel discussion: Can industry fill the gaps? 

Day 2 (8 July 2014)
Market research, incremental value, diagnostic thinking impact, reference standards, patient impact, TB Tech Pitch

Panel discussion: What is the market for TB diagnostics?[Not to be posted]

Panel discussion: Optimal reference standards for test evaluation

Diagnostic prediction models and incremental value - S Schumacher [Download]

Impact of test results on diagnostic thinking - M Pai [Download]

Diagnostic RCTs in TB: Same-day smear diagnosis- A Ramsay [Download]

Diagnostic RCTs in TB: Xpert MTB/RIF - G Theron [Download]

TB tech pitch [Not to be posted]

Day 3 (9 July 2014)
Implementation research, qualitative research

Panel discussion: Measuring clinical impact: methodological issues and challenges [Slides]

Implementation research in TB diagnostics: case studies - A Cattamanchi [Download]

Implementation research in TB diagnostics: case studies - A Ramsay [Download]

Barriers to POC testing: insights from qualitative research - N Engel [Download]

Xpert MTB/RIF in high incidence settings: TB REACH experience - J Creswell [Download]

Importance of reproducibility: case study of IGRAs - N Banaei [Download]

Panel discussion: Are high burden countries ready for molecular tests? [Slides]

Day 4 (10 July 2014)
Meta-analysis, GRADE, guidelines, modeling

Systematic reviews of diagnostic accuracy - K Steingart [Download]

SR: case study: Xpert for EPTB - S Schumacher [Download]

SR: case study: Predictive value of IGRAs and TST - S Kik [Not to be posted]

Guideline development in TB diagnostics - K Steingart [Download]

Panel discussion: How do countries make policies on new diagnostics?

Mathematical modeling: an introduction - D Dowdy [Download]

Day 5 (11 July 2014)
Modeling, cost effectiveness

Transmission modeling of TB diagnostics - D Dowdy [Download]

Cost-effectiveness analysis of TB diagnostics - D Dowdy [Download]

Challenges in modeling TB diagnostics - D Dowdy [Download]

Modeling for decision-making - D Dowdy [Download]

Panel discussion: Linking models to decision-making in public health & policy 

Modeling and cost-effectiveness: a synthesis - D Dowdy [Download]